|
KMID : 0923620120120030126
|
|
Immune Network
2012 Volume.12 No. 3 p.126 ~ p.128
|
|
|
A Case of Drug-Induced Hepatitis due to Bortezomib in Multiple Myeloma
|
|
Kim Young-Woon
Kim Ka-Young
Lee Su-Hyun
Chung Yoon-Yung
Yahng Seung-Ah
Lee Sung-Eun
Park Gyeong-Sin
Min Chang-Ki
|
|
|
Abstract
|
|
|
|
We report on a case of severe hepatotoxicity in a 52-year-old male with multiple myeloma (MM) who had received bortezomib therapy. At patient presentation, liver enzymes were normal, but started to markedly increase 3 days after the patient’s second dose of bortezomib was administered, when free kappa light chains were noticeably reduced in the serum. After discontinuation of bortezomib, liver enzymes recovered gradually to baseline. Then, the patient was started on a thalidomide-containing regimen, which he was able to tolerate well. The patient achieved complete remission prior to autologous stem cell transplantation (ASCT). The patient underwent ASCT without occurrence of further liver toxicity.
|
|
|
KEYWORD
|
|
|
Bortezomib, Hepatotoxicity, Multiple myeloma
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
   
|